Thor, the Thundergod who first encountered with the Destroying Legion, suffered a severe blow. Loki was killed, and the Space Gem fell into the hands of the Destroying Legion. Shortly after, the vanguard troops who destroyed the tyrants killed the earth, and after a series of struggles, they captured Dr. Strange. To prevent the Time Gem from falling into the enemy's hands, Stark and Spider Man broke into the enemy's ship. At the same time, the illusion of possessing a spiritual gem was also attacked by alien invaders. Therefore, the US captain, the Black Widow, and others took him to the Kingdom of Wakanda to seek help from the Black Panther. Surviving the disaster, Sol met the Xingjue and his party, and then their troops split into two routes. Sol, Rocket, and Grunt embarked on the journey of recasting the Hammer of Thor, while Starlord and Camorra, among others, tried to prevent the evil deeds of destroying the tyrants. And Kamala, who knows the whereabouts of the Soul Gem, is also the target of his righteous father's pursuit of Vanquishing the Overlord.The epic battle that concerns the fate of the entire universe is in full swing, with superheroes desperate for ordinary and free lives

最先與滅霸軍團遭遇的雷神索爾一行遭遇慘烈打擊，洛基遇害，空間寶石落入滅霸之手。 未幾，滅霸的先鋒部隊殺至地球，一番纏鬥後擄走奇异博士。 為封锁時間寶石落入敵手，斯塔克和蜘蛛人闖入了敵人的飛船。 與此同時，擁有心靈寶石的幻視也遭到外星侵略者的襲擊，為此美國隊長、黑寡婦等人將其帶到瓦坎達王國，向黑豹求助。 倖免於難的索爾與星爵一行相逢，隨後他們兵分兩路。 索爾與火箭、格魯特踏上再鑄雷神之錘的旅程，星爵則與卡魔拉等人試圖封锁滅霸的惡行。 而知曉靈魂寶石下落的卡魔拉，同樣是其義父滅霸追跡的對象。攸關整個宇宙命運的史詩戰役全面展開，超級英雄們為了平凡而自由的生命奮不顧身……